Immunodeficiency Disorders MCQs with Answers

adminApril 3, 2024

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Welcome to the Immunodeficiency Disorders MCQs with Answers. In this post, we have shared Immunodeficiency Disorders Online Test for different competitive exams. Find practice Immunodeficiency Disorders Practice Questions with answers in Biology Tests exams here. Each question offers a chance to enhance your knowledge regarding Immunodeficiency Disorders.

These are conditions characterized by inappropriate responses of the body’s immune system to infections and diseases. They are broadly classified according to causation into primary or genetic and secondary or acquired. Most of them are genetic; hence they refer to mutations in genes that affect the functions of cells of the immune system and thus predispose patients to infections. Examples of primary immunodeficiencies include SCID and CVID.

Secondary immunodeficiencies, acquired and due to etiologic factors exogenous to the patient himself, such as infections, malnutrition or immunosuppressive drugs. Probably the most known and frequent secondary immunodeficiency disease is HIV infection that leads to Acquired Immunodeficiency Syndrome (AIDS).

The diagnosis is accompanied by clinical evaluation, immunological testing, and genetic analysis. The patients need early diagnosis coupled with intervention to avoid severe complications in the conditions. Treatment could therefore be administered mainly through immunoglobulin replacement therapy, antibiotics to prevent infections, and sometimes through a stem cell or bone marrow transplant.

The scientific and clinical research of immunodeficiency diseases, such as HIV/AIDS, focuses on understanding the disease mechanism due to genetic or environmental factors that cause immunodeficiency disorders. There have been various advancements in different fields: diagnostic techniques, specific therapies, and the fate of the patient.

Immunodeficiency Disorders Online Quiz

By presenting 3 options to choose from, Immunodeficiency Disorders Quiz which cover a wide range of topics and levels of difficulty, making them adaptable to various learning objectives and preferences. You will have to read all the given answers of Immunodeficiency Disorders Questions and Answers and click over the correct answer.

Test Name: Immunodeficiency Disorders MCQ Quiz Practice
Type: Quiz Test
Total Questions: 40
Total Marks: 40
Time: 40 minutes

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Immunodeficiency Disorders

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1 / 40

Which disorder is characterized by the inability to produce antibodies?

Neutropenia

Lymphopenia

Agammaglobulinemia

2 / 40

Which primary immunodeficiency is often treated with bone marrow transplantation?

Hyper IgM Syndrome

Selective IgA Deficiency

Severe Combined Immunodeficiency (SCID)

3 / 40

The absence of the thymus is a hallmark of which syndrome?

Bruton’s Agammaglobulinemia

DiGeorge Syndrome

Common Variable Immunodeficiency

4 / 40

A patient with recurrent bacterial infections and low levels of all immunoglobulins might have?

Chronic Granulomatous Disease

Selective IgA Deficiency

Common Variable Immunodeficiency

5 / 40

What is the genetic inheritance pattern of Wiskott-Aldrich Syndrome?

Autosomal recessive

Autosomal dominant

X-linked recessive

6 / 40

A deficiency in which complement component can lead to recurrent Neisseria infections?

C5-C9

C1 esterase

7 / 40

Which of the following is a primary immunodeficiency disorder?

Severe Combined Immunodeficiency (SCID)

Tuberculosis

HIV/AIDS

8 / 40

Which syndrome is associated with defective T-cell development and low calcium levels?

Severe Combined Immunodeficiency (SCID)

Hyper IgM Syndrome

DiGeorge Syndrome

9 / 40

The "Boy in the Bubble" disease refers to?

Severe Combined Immunodeficiency (SCID)

Common Variable Immunodeficiency

X-linked agammaglobulinemia

10 / 40

Hyper IgM syndrome is characterized by high levels of which immunoglobulin?

IgG

IgM

IgA

11 / 40

In X-linked agammaglobulinemia, the BTK gene mutation affects the development of?

T cells

Natural killer cells

B cells

12 / 40

Which primary immunodeficiency can present with eczema, thrombocytopenia, and recurrent infections?

DiGeorge Syndrome

Wiskott-Aldrich Syndrome

Hyper IgM Syndrome

13 / 40

The diagnostic hallmark of Chronic Granulomatous Disease is?

Lack of thymus

Defective neutrophil function

Low immunoglobulin levels

14 / 40

DiGeorge Syndrome is primarily caused by?

A mutation in the B cell receptor

An HIV infection

A deletion on chromosome 22

15 / 40

Common Variable Immunodeficiency (CVID) usually presents with?

Autoimmune disorders

Allergic reactions

Recurrent infections

16 / 40

Wiskott-Aldrich Syndrome is caused by mutations in which gene?

IL-2 receptor gene

BTK gene

WAS gene

17 / 40

Wiskott-Aldrich Syndrome affects which type of cells primarily?

Endothelial cells

Red blood cells

Platelets and immune cells

18 / 40

Which disorder is characterized by an inability to clear certain fungal and bacterial infections?

Chronic Granulomatous Disease

Common Variable Immunodeficiency

DiGeorge Syndrome

19 / 40

Selective IgA deficiency mainly affects which immunoglobulin?

IgA

IgG

IgM

20 / 40

The absence of mature B cells is indicative of which condition?

Hyper IgM Syndrome

Chronic Granulomatous Disease

X-linked agammaglobulinemia

21 / 40

Which immunodeficiency is associated with defects in the phagocyte oxidase enzyme?

DiGeorge Syndrome

Chronic Granulomatous Disease

Wiskott-Aldrich Syndrome

22 / 40

Hyper IgM Syndrome involves a defect in which gene?

TCR gene

CD40 ligand

IL-2 receptor

23 / 40

What is the most common primary immunodeficiency?

Selective IgA deficiency

DiGeorge Syndrome

Common Variable Immunodeficiency

24 / 40

Job's Syndrome is also known as?

Hyper IgM Syndrome

Hyper IgE Syndrome

Hypogammaglobulinemia

25 / 40

Hyper IgM Syndrome can result from mutations in which of the following?

CD40 ligand

Complement factor

IgA receptor

26 / 40

Which primary immunodeficiency disorder involves a defect in the CD40 ligand gene?

Selective IgA Deficiency

Hyper IgM Syndrome

Common Variable Immunodeficiency

27 / 40

What is the treatment of choice for Bruton's Agammaglobulinemia?

Corticosteroids

Antifungal medication

Immunoglobulin replacement therapy

28 / 40

Ataxia-telangiectasia is associated with which kind of defect?

Protein folding

Enzyme production

DNA repair

29 / 40

What is the main characteristic of X-linked agammaglobulinemia?

Overproduction of B cells

Deficiency of T cells

Lack of B cells

30 / 40

Chronic Granulomatous Disease is diagnosed using which test?

Nitroblue tetrazolium test

Flow cytometry

ELISA

31 / 40

Which primary immunodeficiency involves a defect in neutrophil chemotaxis?

Common Variable Immunodeficiency

Leukocyte Adhesion Deficiency

Bruton’s Agammaglobulinemia

32 / 40

What is a common treatment for many primary immunodeficiency disorders?

Immunoglobulin replacement therapy

Antiviral drugs

Antibiotics

33 / 40

Wiskott-Aldrich Syndrome includes symptoms like?

Thrombocytopenia, eczema, recurrent infections

Only eczema

Only recurrent infections

34 / 40

Defects in the IL-2 receptor gamma chain can result in which immunodeficiency?

Chronic Granulomatous Disease

Severe Combined Immunodeficiency (SCID)

Selective IgA Deficiency

35 / 40

Severe Combined Immunodeficiency (SCID) affects which cells?

Only T cells

Both B and T cells

Only B cells

36 / 40

Ataxia-telangiectasia is associated with increased risk of which disease?

Osteoporosis

Cardiovascular disease

Cancer

37 / 40

The primary cause of death in patients with Severe Combined Immunodeficiency (SCID) is?

Autoimmune diseases

Infections

Cancer

38 / 40

Chronic mucocutaneous candidiasis is primarily due to a defect in which type of cell?

B cells

Phagocytes

T cells

39 / 40

Selective IgA deficiency often results in?

Mucosal infections

Muscle weakness

Blood clotting disorders

40 / 40

Which enzyme deficiency leads to Severe Combined Immunodeficiency (SCID)?

Alpha-1 antitrypsin

Adenosine deaminase

Phosphofructokinase

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adminApril 3, 2024

0 48 2 minutes read