Gene Therapy MCQs with Answers

adminJune 13, 2024

0 9 2 minutes read

Welcome to the Gene Therapy MCQs with Answers. In this post, we have shared Gene Therapy Online Test for different competitive exams. Find practice Gene Therapy Practice Questions with answers in Biology Tests exams here. Each question offers a chance to enhance your knowledge regarding Gene Therapy.

Gene therapy represents a new kind of medical treatment that might one day treat, even prevent, specific genetic disorders by inserting, deleting, or altering the genetic material inside a patient’s cells. That is why it promises cure rather than mere management of symptoms.

The principle of the gene therapy is to transfer a normal healthy copy of the gene or correct the defective genes to regain normal functions.

These have ranged from the delivery of therapeutic genes using viral vectors targeting cells to the use of CRISPR-Cas9 as a highly accurate gene editing tool. This promise does make gene therapy capable of either replacing faulty genes or correcting mutations that treat both diverse diseases including inherited disorders such as cystic fibrosis and hemophilia and those complex diseases like cancer.

These have been quite promising clinical trials and research in gene therapy. Indeed, several therapies have reached the stage whereby they are now approved for clinical use. A case in point is Luxturna, a gene therapy developed to treat inherited retinal dystrophy. Comparably, Zolgensma provides unprecedented treatment for spinal muscular atrophy. However, gene therapy has its limitation: ethical concerns, very high costs, and unknown long-term effects; therefore, active research and development to solve some of these issues, improve delivery methods, and be sure that the gene therapy is safe and effective.

Today, it remains one of the most advanced levels of personalized medicine and has a prospect for people with previously untreated genetic diseases, thereby opening further innovation in the realm of medical treatment.

Gene Therapy Online Quiz

By presenting 3 options to choose from, Gene Therapy Quiz which cover a wide range of topics and levels of difficulty, making them adaptable to various learning objectives and preferences. You will have to read all the given answers of Gene Therapy Questions and Answers and click over the correct answer.

Test Name: Gene Therapy MCQ Quiz Practice
Type: Quiz Test
Total Questions: 40
Total Marks: 40
Time: 40 minutes

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Gene Therapy

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1 / 40

Which of the following is an example of a monogenic disorder that could be treated with gene therapy?

Hypertension

Cystic fibrosis

Type 2 diabetes

2 / 40

What is the term for gene therapy that targets cancer cells specifically?

CAR-T therapy

Suicide gene therapy

Oncogene therapy

3 / 40

Which regulatory agency oversees the approval of gene therapy products in the United States?

FDA

EMA (European Medicines Agency)

MHRA (Medicines and Healthcare products Regulatory Agency)

4 / 40

Which regulatory challenge is specific to gene therapy compared to traditional drugs?

Long-term safety monitoring

Manufacturing scalability

Short-term efficacy

5 / 40

Which of these is a potential safety concern in using CRISPR/Cas9 for gene therapy?

Vector integration

Promoter activity

Off-target effects

6 / 40

Which term describes the delivery of genetic material using ultrasound?

Photoporation

Electroporation

Sonoporation

7 / 40

Which of these is a potential side effect of gene therapy using viral vectors?

Enhanced metabolic activity

Decreased gene expression

Immune response

8 / 40

Which of these is a potential limitation of CRISPR/Cas9 technology in gene therapy?

Off-target effects

Inability to cross cell membranes

Limited gene size

9 / 40

In which phase of clinical trials is gene therapy typically tested for safety and efficacy?

Phase III

Phase I

Phase II

10 / 40

Which of the following is a potential advantage of using non-viral vectors in gene therapy?

Higher cargo capacity

Reduced immunogenicity

Ability to infect dividing cells

11 / 40

What is the term for gene therapy aimed at modifying germ cells (sperm or egg cells)?

Germline gene therapy

In vivo gene therapy

Somatic gene therapy

12 / 40

Which delivery method involves directly injecting the therapeutic vector into the affected tissue?

In vivo gene therapy

Ex vivo gene therapy

In situ gene therapy

13 / 40

What is the main purpose of gene therapy?

Improving organ function

Enhancing immune response

Correcting faulty genes

14 / 40

What is the term for a gene that can cause cancer when mutated or overexpressed?

Proto-oncogene

Oncogene

Tumor suppressor gene

15 / 40

Which of the following is NOT a potential application of gene therapy?

Treating genetic disorders

Enhancing cognitive function

Curing bacterial infections

16 / 40

What is the term for a regulatory sequence that controls the timing and level of gene expression?

Promoter

Operator

Enhancer

17 / 40

What is the most common route of administration for gene therapies targeting the liver?

Intravenous injection

Subcutaneous injection

Intramuscular injection

18 / 40

Which term describes a stable integration of introduced genes into the host cell's genome?

Transgene

Transposon

Transcription factor

19 / 40

Which type of gene therapy aims to correct genetic mutations in mitochondrial DNA?

Mitochondrial gene therapy

Nuclear gene therapy

Plasmid gene therapy

20 / 40

Which type of gene therapy aims to inhibit the expression of a particular gene?

Insertional mutagenesis

Antisense therapy

Overexpression therapy

21 / 40

Which type of gene therapy involves correcting mutations in the DNA of mitochondria?

Mitochondrial gene therapy

Plasmid gene therapy

Nuclear gene therapy

22 / 40

What is the primary challenge of using viral vectors in gene therapy?

Immunogenicity

Difficulty in replication

Limited cargo capacity

23 / 40

Which type of viral vector is derived from adenovirus and commonly used in gene therapy?

Lentivirus

Adeno-associated virus (AAV)

Retrovirus

24 / 40

What is the primary reason for using CRISPR/Cas9 in gene therapy?

Immune system activation

Precise gene editing

Gene expression regulation

25 / 40

Which gene therapy approach involves inserting a new gene into a random location in the genome?

In situ gene therapy

Insertional mutagenesis

Ex vivo gene therapy

26 / 40

What is the term for a segment of DNA that is capable of moving and replicating within the genome?

Promoter

Transposon

Enhancer

27 / 40

Which of these is a potential challenge in delivering gene therapy to the brain?

Limited receptor expression

Rapid cellular turnover

Blood-brain barrier

28 / 40

What is the primary advantage of using lentiviral vectors in gene therapy?

Transduce dividing and non-dividing cells

Low immunogenicity

High cargo capacity

29 / 40

What is the term for the process of introducing new genetic material into cells to correct a genetic defect?

Transduction

Transformation

Transfection

30 / 40

Which term describes the technique of introducing DNA into cells using electric shock?

Electroporation

Photoporation

Sonoporation

31 / 40

Which enzyme is commonly used in CRISPR gene editing to cut DNA at specific sequences?

DNA polymerase

Cas9

Reverse transcriptase

32 / 40

Which delivery method involves extracting cells, modifying them in vitro, and reinfusing them into the patient?

In situ gene therapy

Ex vivo gene therapy

In vivo gene therapy

33 / 40

Which term describes the transfer of genetic material from one organism to another?

Transduction

Transformation

Transfection

34 / 40

In gene therapy, what does the acronym "CRISPR" stand for?

Clustered regularly interspaced short palindromic repeats

Cellular reprogramming

Gene editing

35 / 40

Which of these is a potential ethical concern in gene therapy?

Physical therapy

Blood transfusion

Germline modification

36 / 40

Which term describes the process of introducing genes into stem cells to treat genetic disorders?

Stem cell transformation

Stem cell transfection

Stem cell transduction

37 / 40

What is the term for gene therapy aimed at modifying somatic cells?

Germline gene therapy

Ex vivo gene therapy

Somatic gene therapy

38 / 40

What is the term for a vector that can replicate independently of the host cell's genome?

Insertional vector

Shuttle vector

Episome

39 / 40

Which of the following is a non-viral vector used in gene therapy?

Lentivirus

Liposome

Adenovirus

40 / 40

Which vector is commonly used in gene therapy to deliver genes into target cells?

Plasmid vectors

Liposomal vectors

Viral vectors

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adminJune 13, 2024

0 9 2 minutes read